Dr. Stephen Harrison works on the structure of viruses and viral proteins, as examined at high resolution by x-ray crystallography and, more recently, by cryoEM. He has studied the surface glycoproteins of flaviviruses, herpesviruses, coronaviruses, arenaviruses, and HIV/SIV, as well the HA-mediated fusion mechanisms of influenza virus. The last of these projects has included collaboration with Dr. Whelan. His recent work on dengue virus fusion inhibitors, in collaboration with Dr. Yang, has provided important preliminary results for Project 1. Dr. Harrison's deep understanding of virus structure and molecular mechanisms of viral entry will contribute to all facets of this CETR